Big data and artificial intelligence (“AI”) promise to transform virtually all aspects of biomedical research and health care (Matheny et al. 2019), through facilitation of drug development, diagno...

Digital contact tracing, in combination with widespread testing, has been a focal point for many plans to “reopen” economies while containing the spread of Covid‐19. Most digital contact tracing projects in the United States and Europe have prioritized privacy protections in the form of local storage of data on smartphones and the deidentification of information. However, in the prioritization of privacy in this narrow form, there is not sufficient attention given to weighing ethical trade‐offs within the context of a public (...) health pandemic or to the need to evaluate safety and effectiveness of software‐based technology applied to public health. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

McCradden et al. propose to close the “AI chasm” between algorithms and clinically meaningful application using the norms of evidence-based medicine and clinical research, with the rat...

Mildred Cho and Nicole Martinez-Martin (2023) distinguish between two of the ways in which humans can be represented in medical contexts. One is technical: a digital model of aspects of a person’s...

While considerations of gender predominate in scholarly accounts of why and how people derive pleasure from videogame play, the question of sex remains either undertheorized or conspicuously absent from the conversation. Drawing on Jacques Lacan’s formulae of sexuation, this article argues that the jouissance (enjoyment) of videogame play is sexed rather than gendered. It theorizes two logics of enjoyment in videogame play: enjoyment with exception and enjoyment without exception. Through an analysis of the videogame Inside, it argues that the logic (...) of enjoying without exception undergirds the libidinal satisfaction of all videogame play. To accept that the enjoyment of videogame play is predicated on such a logic, however, means to accept the ontological failure of the sexual relation. Videogame culture is subsequently founded on a disavowal of the logic of enjoying without exception and a pathological identification with the logic of enjoying with exception. (shrink)

Of the various contests held by Aeneas to mark the anniversary of his father's death the ship-race is marked out by its length and initial position as especially important. However its precise significance is by no means obvious. That Virgil intends it to have some relevance to events of later Roman history seems fairly clear. First, we are told the names of the families descended from three of the four captains involved — Cluentii, Memmii and Sergii. It seems therefore that (...) we should look to the activities of members of these families to discover Virgil's intention. Two families — Cluentii and Memmii — are a mystery, since none of their members plays an obviously prominent role in the events of Virgil's own time. However, Sergestus and the Sergii point unmistakably towards Catiline. Sergestus' rash folly, which is nearly the ruin of his men and his ship, exactly matches Catifine's own furor, which would have destroyed Rome. Even the name of his ship, Centaurus, reinforces the point. (shrink)

While the fundamental laws of physics are time-reversal invariant, most macroscopic processes are irreversible. Given that the fundamental laws are taken to underpin all other processes, how can the fundamental time-symmetry be reconciled with the asymmetry manifest elsewhere? In statistical mechanics, progress can be made with this question. What I dub the ‘Zwanzig–Zeh–Wallace framework’ can be used to construct the irreversible equations of SM from the underlying microdynamics. Yet this framework uses coarse-graining, a procedure that has faced much criticism. I (...) focus on two objections in the literature: claims that coarse-graining makes time-asymmetry ‘illusory’ and ‘anthropocentric’. I argue that these objections arise from an unsatisfactory justification of coarse-graining prevalent in the literature, rather than from coarse-graining itself. This justification relies on the idea of measurement imprecision. By considering the role that abstraction and autonomy play, I provide an alternative justification and offer replies to the illusory and anthropocentric objections. Finally, I consider the broader consequences of this alternative justification: the connection to debates about inter-theoretic reduction and the implication that the time-asymmetry in SM is weakly emergent. 1Introduction 1.1Prospectus2The Zwanzig–Zeh–Wallace Framework3Why Does This Method Work? 3.1The special conditions account3.2When is a density forwards-compatible?4Anthropocentrism and Illusion: Two Objections 4.1The two objections in more detail4.2Against the justification by measurement imprecision5An Alternative Justification 5.1Abstraction and autonomy5.2An illustration: the Game of Life6Reply to Illusory7Reply to Anthropocentric8The Wider Landscape: Concluding Remarks 8.1Inter-theoretic relations8.2The nature of irreversibility. (shrink)

Over the last twenty years there has been increasing interest in the work of Michel Foucault in the social sciences and in particular with relation to education. This, the first book to draw on his work to consider lifelong learning, explores the significance of policies and practices of lifelong learning to the wider societies of which they are a part. With a breadth of international contributors and sites of analysis, this book offers insights into such questions as: What are the (...) effects of lifelong learning policies within socio-political systems of governance? What does lifelong learning do to our understanding of ourselves as citizens? How does lifelong learning act in the regulation and re-ordering of what people do? The book suggests that understanding of lifelong learning as contributory to the knowledge economy, globalisation or the new work order may need to be revised if we are to understand its impact more fully. It therefore makes a significant contribution to the study of lifelong learning. (shrink)

In the history of Archaic Greece no event stands out so clearly as the First Sacred War. The War took place in the years round 590 B.C., and ended with the capture and destruction of the great city of Crisa at the hands of a coalition of powers which included Sicyon, Athens, and Thessaly. Our sources provide a wealth of detail–the causes of the War, the names of half-a-dozen commanders and champions, the stages of the fighting, the victory celebrations and (...) dedications which ensued, certain Delphic oracles and Amphictyonic decrees. (shrink)

Since the appearance of Dodds's edition of Gorgias a number of the dialogues in tetr. I-VII have benefited from a re-examination of the evidence for the Platonic text—most notably Meno, tetr. IV, Parmenides, and Phaedrus. Recently the textual tradition of Phaedo has been studied by A. Carlini in a useful book which traces the fortunes of the text from antiquity until the time of the major manuscripts. The evidence thus accumulated goes some way to lessening a problem which has long (...) been obvious—the difficulty of studying the tradition of any single dialogue in isolation from the rest of the Platonic corpus. I propose to argue, however, that the bulk of evidence now available for several dialogues should not blind us to another hazard—that of attempting to fit dialogues showing different textual features into what is basically a single stemmatic pattern. (shrink)

Pt. I. Philosophy and cognitive-behavioral therapy (CBT) -- Ch. 1. The "philosophical origins" of CBT -- Ch. 2. The beginning of modern cognitive therapy -- Ch. 3. A brief history of philosophical therapy -- Ch. 4. Stoic philosophy and psychology -- Ch. 5. Rational emotion in stoicism and CBT -- Ch. 6 Stoicism and Ellis's rational therapy (REBT) -- Pt. II. The stoic armamentarium -- Ch. 7. Contemplation of the ideal stage -- Ch. 8. Stoic mindfulness of the "here and (...) now" -- Ch. 9. Self-analysis and disputation -- Ch. 10. Autosuggestion, premeditation, and retrospection -- Ch. 11. Preditatio malorum and mental rehearsal -- Ch. 12. Stoic fatalism, determination, and acceptance -- Ch. 13. The view from above and stoic metaphysics. (shrink)

Indirect situationist critiques of virtue ethics grant that virtue exists and is possible to acquire, but contend that given the low probability of success in acquiring it, a person genuinely interested in behaving as morally as possible would do better to rely on situationist strategies - or, in other words, strategies of environmental or ecological engineering or control. In this paper, I develop a partial answer to this critique drawn from work in early Confucian ethics and in contemporary philosophy and (...) psychology. From early Confucian ethics, I lean on the concept of li, or ritual. Ritual represents both a set of situational manipulations that are especially effective at directly producing moral behavior and at indirectly cultivating virtue over time, and also a virtue that consists of facility with and expertise in these situational manipulations. Appealing to the particular example of social power, I then argue that one is justified in attempting to acquire virtue if one knows that one will frequently encounter circumstances in which purely situationist strategies lose effectiveness, if these circumstances also carry moral urgency: the risk of great harm or opportunity for great benefit to others is high, and if utilizing the potent combination of situationist strategies and virtue envisioned by the early Confucians as ritual is possible. (shrink)

With the growth of precision medicine research on health data and biospecimens, research institutions will need to build and maintain long-term, trusting relationships with patient-participants. While trust is important for all research relationships, the longitudinal nature of precision medicine research raises particular challenges for facilitating trust when the specifics of future studies are unknown. Based on focus groups with racially and ethnically diverse patients, we describe several factors that influence patient trust and potential institutional approaches to building trustworthiness. Drawing on (...) these findings, we suggest several considerations for research institutions seeking to cultivate long-term, trusting relationships with patients: Address the role of history and experience on trust, engage concerns about potential group harm, address cultural values and communication barriers, and integrate patient values and expectations into oversight and governance structures. (shrink)

What is the relation between what we ought to do, on the one hand, and our epistemic access to the ought-giving facts, on the other? In assessing this,it is common to distinguish ‘objective’ from ‘subjective’ oughts. Very roughly, on the objectivist conception what an agent ought to do is determined by ought-giving facts in such a way that does not depend on the agent’s beliefs about, or epistemic access to, those facts; whereas on the subjectivist conception, what an agent ought (...) to do depends on his beliefs. This paper defends the need for, and explicates, a third category of ‘ought’: ‘warranted oughts’. Section 1 introduces the distinction between objective and subjective ‘oughts’. Sections 2–3 draw attention to some serious problems with each. Section 4 examines, though rejects, a recent attempt to replace subjective ‘oughts’ with objective ‘wide-scope oughts’ operating on belief-action combinations. Section 5 explicates the notion of a warranted ‘ought’ and defends the account against some possible objections. The resulting a picture is one in which an adequate analysis of practical normativity requires both objective and warranted ‘oughts’. Section 6 concludes by responding to a worry about countenancing both. (shrink)

The scarcity of vital organs has prompted several calls to either modify the dead donor rule or interpret it more broadly. Given its symbolic importance, however, the rule should be changed only cautiously.

The idea of splitting off cells from embryos to clone human beings sounds so bizarre and dangerous that one would think the practice should not be permitted. A closer look reveals its ethical acceptability.

Advance directives such as living wills are attractive in that they give us a sense of control over our futures. But they also tend to obscure conflicts between a patient's competent wishes and later, incompetent interests. They allow caregivers to avoid evaluating quality of life in assessing the best interests of incompetent patients.

In this paper we theorize that cognitive ethical orientations play an influential role in the beliefs of consumers when faced with different ranges of moral dilemmas. We examine this proposition in transitional Eastern Europe and results from a sample of 210 Romanian consumers suggest that Romanians are faced with a moral situation where low levels of Machiavellianism and high levels of idealism appear to relate to a higher ethical concern about passively benefiting at the expense of others.

From its inception, genomics has been a speculative endeavor, fixated on a far-off horizon that would deliver on the promise of targeted diagnostics and individualized therapeutics (Fortun 2008). M...

Ethical and legal traditions recognize prenatal duties to avoid harm to offspring. However, applying the harm principle to pregnancy requires a careful balancing of a baby's welfare with a pregnant woman's interest in liberty and bodily integrity. In the case of maternal PKU the mother can prevent harm to her baby by returning to the admittedly unpleasant diet that prevented her from being retarded. Informing, counseling, and access to medical care should be the primary policy. Seizures and forced treatment cannot (...) be justified in this case, and only rarely in other situations. (shrink)

The distinction between essential versus accidental properties has been characterized in various ways, but it is currently most commonly understood in modal terms: an essential property of an object is a property that it must have, while an accidental property of an object is one that it happens to have but that it could lack. Let’s call this the basic modal characterization, where a modal characterization of a notion is one that explains the notion in terms of necessity/possibility. In the (...) characterization just given of the distinction between essential and accidental properties, the use of the word “must” reflects the fact that necessity is invoked, while the use of the word “could” reflects that possibility is invoked. The notions of necessity and possibility are interdefinable: to say that something is necessary is to say that its negation is not possible; to say that something is possible is to say that its negation is not necessary; to say that an object must have a certain property is to say that it could not lack it; and to say that an object could have a certain property is to say that it is not the case that it must lack it. (shrink)

A significant portion of recent literature on Nietzsche is devoted to his metaethical views, both critical and positive. This article explores one aspect of his positive metaethics. The specific thesis defended is that Nietzsche is, or is plausibly cast as, a reasons internalist. This, very roughly, is the view that what an agent has normative reason to do depends on that agent's motivational repertoire. Section I sketches some of the metaethical terrain most relevant to Nietzsche's organising ethical project, his “revaluation (...) of all values”, and lays out three “design-requirements” that an adequate account of Nietzsche's metaethical views must satisfy. Section II introduces the basic internalist position. Sections III–IV provide textual support for the internalist reading of Nietzsche, with Section V showing how it meets each of the design-requirements. Section VI concludes by showing how the internalist apparatus also illuminates Nietzsche's views about the process of revaluing values. (shrink)

In this paper, I examine the case that has been made for origin essentialism and find it wanting. I focus on the arguments of Nathan Salmon and Graeme Forbes. Like most origin essentialists, Salmon and Forbes have been concerned to respect the intuition that slight variation in the origin of an artifact or organism is possible. But, I argue, both of their arguments fail to respect this intuition. Salmon's argument depends on a sufficiency principle for cross-world identity, which should be (...) rejected, if - as Salmon concedes - a given artifact might have been originally made from slightly different material. Similarly, Forbes's argument succeeds only if essentially the same argument can be used to establish a claim that - by his own admission - is too strong, namely that no variation, however slight, in an organism's origin is possible. (shrink)

This collection of papers is as welcome as it is overdue. As its editors observe in their introduction, the reference point for studies of Hume’s economic thinking has remained Eugene Rotwein’s “Introduction” to his volume David Hume: Writings on Economics (Madison: University of Wisconsin Press) since its publication in 1955. The conference from which these papers derive was convened forty-eight years later, in 2003, and the volume was another five years in preparation (while this review, in turn, has taken its (...) own time). But David Hume’s Political Economy is not a random collection of conference papers: editorial direction has ensured a substantial publication, and an important contribution to Hume studies. The .. (shrink)

Development of the knowledge base for a profession depends on research and scholarship that builds on the insights and work of scholars within the discipline and is disseminated through the literature. The purpose of this study was to examine a unique collection of 79 articles selected by editors as representative of their nursing journals. Articles were assessed for congruence with long‐standing values and conceptual definitions of nursing, and the extent to which they built on prior literature published in nursing. Articles (...) were scored based on whether they reflected four characteristics of nursing as a discipline (holism, social context, goal of health, and consistency with common definitions of nursing); an abstract score on the extent to which the title, abstract, or keywords indicated a general focus on nursing; and a distinction score based on whether the article distinguished nurses or nursing from other providers. Fifty of the articles received an article score of 4, indicating all four disciplinary characteristics were present in the article's content. While the majority of the articles were congruent with fundamental nursing values and perspectives, only 28% of the sources cited were from nursing sources. The lack of citations to nursing literature, coupled with an assessment that reveals gaps in substantive content that builds on nursing knowledge, raises questions about the future of nursing perspectives in the literature. (shrink)

Physically frail, badly educated girls, brought up to lead useless lives as idle gentlewomen, married to dominant husbands, and relegated to "separate spheres" of life—these phrases have often been used to describe Victorian upper-middle-class women. M. Jeanne Peterson rejects such formulations and the received wisdom they embody in favor of a careful examination of Victorian ladies and their lives. Focusing on a network of urban professional families over three generations, this book examines the scope and quality of gentlewomen's education, their (...) physical lives, their relationship to money, their experience of family illness and death, and their relationships to men (brothers and friends as well as fathers and husbands). Peterson also examines the prominent place of work in the lives of these "leisured" Victorian ladies, both single and married. Far from idle, the mothers, wives, and daughters of Victorian clergymen, doctors, lawyers, university dons, and others were accomplished and productive members of society who made substantial public and private contributions to virtually every sphere of Victorian life. (shrink)

The U.S. and U.K. models of corporate social responsibility (CSR) are relatively well defined. As the phenomenon of CSR establishes itself more globally, the question arises as to the nature of CSR in other countries. Is a universal model of CSR applicable across countries or is CSR specific to country context? This article uses integrative social contracts theory (ISCT) and four institutional factors – firm ownership structure, corporate governance, openness of the economy to international investment, and the role of civil (...) society – to examine CSR in Singapore, Turkey, and Ethiopia. Field research results illustrate variation across the institutional factors and suggest that CSR is responsive to country differences. Research findings have implications for consideration of the tradeoff between global and local CSR priorities and practices. (shrink)

Despite an increase in international business ethics research in recent years, the number of studies focused on Latin America and China has been deficient. As trade among Pacific Rim nations increases, an understanding of the ethical beliefs of the people in this region of the world will become increasingly important. In the current study 208 respondents from Peru and China are queried about their ethical ideologies, firm practices, and commitment to organizational performance. The empirical results reveal that Chinese workers are (...) more relativistic and less idealistic than their Peruvian counterparts. One explanation for the disparity between these two groups is likely the variation in collectivism that can be traced to different levels of importance across ingroups and outgroups. In addition to a summary of the results, future research directions and managerial implications are discussed. (shrink)

This volume comprises ten original essays on Nietzsche, one of the western canon's most controversial ethical thinkers. An international team of experts clarify Nietzsche's own views, both critical and positive, ethical and meta-ethical, and connect his philosophical concerns to contemporary debates in and about ethics, normativity, and value.

Over many years, Aharonov and co-authors have proposed a new interpretation of quantum mechanics: the two-time interpretation. This interpretation assigns two wavefunctions to a system, one of which propagates forwards in time and the other backwards. In this paper, I argue that this interpretation does not solve the measurement problem. In addition, I argue that it is neither necessary nor sufficient to attribute causal power to the backwards-evolving wavefunction ⟨Φ| and thus its existence should be denied, contra the two-time interpretation. (...) Finally, I follow Vaidman in giving an epistemological reading of ⟨Φ|. (shrink)

This paper clarifies how to be an error theorist about morality. It takes as its starting point John Mackie’s error theory of the categoricity of moral obligation, defending Mackie against objections from both naturalist moral realists and minimalists about moral discourse. However, drawing upon minimalist insights, it argues that Mackie’s focus on the ontological status of moral values is misplaced, and that the underlying dispute between error theorist and moralist is better conducted at the level of practical reason.

This paper compares the results of large-scale U.S. and U.K. surveys designed to identify managers' major ethical concerns and to investigate how firms are formulating and communicating ethics policies responsive to these concerns.Our findings indicate some important differences between U.S. and U.K. firms in perceptions of what are important ethical issues, in the means used to communicate ethics policies, and in the issues addressed in ethics policies and employee training. U.K. companies tend to be more likely to communicate ethics policies (...) through senior executives, whereas U.S. companies tend to rely more on their Human Resources and Legal Departments. U.S. firms consider most ethical issues to be more important than do their U.K. counterparts, and are especially concerned with employee behavior which may harm the firm. In contrast, the issues which U.K. managers consider more important tend to be concerned with external corporate stakeholders rather than employees. (shrink)